In the frontier of metabolic research, the quest to understand and influence the fundamental cellular processes governing energy homeostasis is relentless. Among the novel compounds attracting significant scientific attention is 5-Amino-1-methylquinolinium, commonly known as 5-Amino-1MQ. GENLABS is proud to introduce its premium, high-purity 5-Amino-1MQ (5mg) vial, meticulously synthesized and validated for the most discerning research applications. This product represents not just a chemical entity, but a precise key designed to probe the intricate workings of nicotinamide N-methyltransferase (NNMT), an enzyme with profound implications for cellular metabolism and bioenergetics.
Our commitment at GENLABS is to empower the scientific community with tools of uncompromising quality. This 5mg vial of 5-Amino-1MQ is manufactured under strict cGMP guidelines, undergoes rigorous third-party analytical testing (HPLC, MS, NMR), and is delivered as a sterile, lyophilized powder to ensure stability and exact dosing for your in-vitro studies. This description outlines the compound's proposed mechanism, potential research vectors, and the unparalleled quality standards that define the GENLABS difference.
5-Amino-1MQ is characterized as a selective, small-molecule inhibitor of the enzyme Nicotinamide N-methyltransferase (NNMT). To appreciate its research utility, one must first understand NNMT's role in cellular physiology.
NNMT catalyzes the methylation of nicotinamide (a form of vitamin B3) using S-adenosyl methionine (SAM) as a methyl donor. This reaction produces 1-methylnicotinamide (MNA) and S-adenosyl homocysteine (SAH). While seemingly niche, this process has cascading effects:
SAM Depletion: SAM is the primary methyl donor for countless cellular processes, including epigenetic regulation (DNA/histone methylation). NNMT activity can consume large amounts of SAM, potentially altering the cellular methylation balance.
Altered NAD+ Precursor Availability: Nicotinamide is a direct precursor for the synthesis of Nicotinamide Adenine Dinucleotide (NAD+), a critical coenzyme in redox reactions and a essential substrate for sirtuins (SIRTs) and poly(ADP-ribose) polymerases (PARPs), which are vital for DNA repair, gene silencing, and mitochondrial function.
Mitochondrial Impact: By potentially influencing NAD+ levels and sirtuin activity, NNMT function is intricately linked to mitochondrial biogenesis and efficiency.
5-Amino-1MQ operates by competitively inhibiting NNMT. By binding to the enzyme's active site, it attenuates the conversion of nicotinamide to MNA. This proposed action is hypothesized to:
Preserve intracellular SAM pools.
Increase the availability of nicotinamide for NAD+ biosynthesis.
Thereby, potentially modulate downstream pathways involving sirtuins, mitochondrial function, and cellular metabolism.
This mechanism positions 5-Amino-1MQ as an invaluable research tool for deconvoluting the complex network linking methyl group metabolism, cellular energetics, and epigenetic regulation.
This compound is intended for laboratory research use only, in controlled in-vitro settings. Key areas of scientific inquiry include:
Metabolic Disorder Research: Investigating the role of NNMT in models of metabolic dysregulation, obesity, and insulin resistance. Studies can explore how NNMT inhibition affects adipocyte metabolism, glucose uptake, and lipid homeostasis.
Mitochondrial Function and Biogenesis: Examining the compound's potential impact on NAD+-dependent pathways, particularly the activation of SIRT1 and PGC-1α, which are master regulators of mitochondrial creation and function. Research may focus on cellular energy expenditure and oxidative capacity.
Aging and Cellular Senescence: Exploring the intersection of metabolism, epigenetics, and aging. Research can assess how modulating the NNMT/NAD+ axis influences markers of cellular senescence, stress resistance, and longevity pathways.
Enzymology and Biochemical Assay Development: Serving as a reference standard for developing high-throughput screens to identify other NNMT modulators or for kinetic studies of the enzyme itself.
Epigenetic Regulation Studies: Probing the indirect effects of NNMT inhibition on global cellular methylation patterns, given its role in SAM consumption, and its subsequent impact on gene expression profiles.
When your research demands certainty, the integrity of your reagents is paramount. The GENLABS 5-Amino-1MQ 5mg vial is the embodiment of our scientific rigor.
Ultra-High Purity: Every batch is synthesized to achieve ≥99% purity, as conclusively verified by independent third-party laboratories using High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS). This ensures your experimental results are attributable to the compound itself, not contaminants.
Structural Confirmation: Nuclear Magnetic Resonance (NMR) spectroscopy is employed to confirm the exact molecular structure and identity of the product, guaranteeing you receive authentic 5-Amino-1MQ.
Sterile Lyophilized Form: The product is supplied as a sterile, lyophilized (freeze-dried) powder in a sealed glass vial. This format maximizes long-term stability, allows for precise reconstitution with your solvent of choice (e.g., sterile saline, bacteriostatic water), and facilitates accurate dosage preparation for cell culture or biochemical assays.
cGMP Manufacturing: Our synthesis facilities operate under current Good Manufacturing Practices (cGMP), ensuring consistent, scalable, and documented production processes from raw materials to finished vial.
Batch-Specific COA: Each vial is traceable to a unique batch number, and a comprehensive Certificate of Analysis (COA) is available upon request. This COA provides full transparency, displaying all analytical data from purity assays to residual solvent and endotoxin testing.
Important Notice: 5-Amino-1MQ from GENLABS is sold strictly for laboratory research purposes only. It is not for human or veterinary use, not for consumption, and must be handled only by qualified researchers in appropriately equipped facilities.
Reconstitution: Carefully add the appropriate volume of sterile solvent to the vial. Gently swirl or roll the vial until the lyophilized powder is completely dissolved. Avoid vigorous shaking to prevent denaturation.
Storage: Store the unopened, lyophilized vial in a cool, dry place, ideally at or below -20°C. Once reconstituted, aliquot the solution to avoid repeated freeze-thaw cycles and store frozen. Always follow proper laboratory safety protocols, including the use of personal protective equipment (PPE).
Research Disclaimer: The biological mechanisms and potential research outcomes described are based on the current scientific literature and are presented for informational purposes to illustrate possible research directions. GENLABS does not make any claims regarding the efficacy or specific results of using this product.
GENLABS stands at the intersection of advanced chemistry and a deep commitment to the research community. We provide more than just peptides and compounds; we provide the foundational materials for discovery. Our 5mg vial of 5-Amino-1MQ offers a potent, reliable, and well-characterized tool to advance your investigations into NNMT and metabolic regulation. By choosing GENLABS, you align your work with a partner dedicated to quality, transparency, and the relentless pursuit of scientific excellence.
Order your 5-Amino-1MQ (5mg) vial today and experience the precision that drives modern research forward.
On all orders is set at $25.00
Protected by Bitcoin
On all huge orders