In the evolving landscape of biochemical research and advanced endocrine studies, Kisspeptin has emerged as a fundamental neuropeptide of profound scientific interest. GenLabs, a name synonymous with precision and purity in peptide science, presents its meticulously formulated Kisspeptin-5mg, complete with a complimentary vial of Bacteriostatic Water. This product is engineered for the exacting demands of clinical research environments, offering researchers a reliable, high-purity tool to explore the intricate pathways of the hypothalamic-pituitary-gonadal (HPG) axis.
This comprehensive description details the science of Kisspeptin, the unparalleled quality of the GenLabs formulation, its primary research applications, and the critical importance of its pairing with bacteriostatic water for optimal reconstitution and stability.
Kisspeptin, encoded by the KISS1 gene, is a potent endogenous neuropeptide that acts as the primary upstream stimulator of Gonadotropin-Releasing Hormone (GnRH) neurons. Its discovery revolutionized the understanding of reproductive physiology. By binding with high affinity to its receptor, GPR54 (Kiss1R), Kisspeptin triggers a cascade that results in the pulsatile secretion of GnRH. This, in turn, stimulates the anterior pituitary gland to release Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH), the key drivers of gonadal function and sex steroid hormone production (estrogen, progesterone, testosterone).
GenLabs' Kisspeptin-5mg typically refers to the Kisspeptin-10 fragment (KP-10), the shortest fully bioactive sequence (amino acids 112-121 of the full protein). This decapeptide retains full biological activity, making it an efficient and potent agent for research purposes.
Every batch of GenLabs Kisspeptin-5mg is a testament to our rigorous quality assurance protocols.
High-Purity Synthesis: Produced using state-of-the-art solid-phase peptide synthesis (SPPS), our Kisspeptin undergoes extensive purification via High-Performance Liquid Chromatography (HPLC) to achieve a purity grade of ≥98%. This minimizes the presence of truncated sequences or impurities that could skew research data.
Mass Spectrometry (MS) Verification: Each vial’s contents are confirmed through mass spectrometry analysis, ensuring the correct molecular weight and amino acid sequence, guaranteeing you receive the authentic, bioactive peptide.
Sterile, Lyophilized Form: The peptide is provided as a sterile, lyophilized (freeze-dried) white powder in a sealed, nitrogen-flushed glass vial to ensure long-term stability and prevent degradation prior to reconstitution.
Complimentary Bacteriostatic Water: Included is a vial of sterile Bacteriostatic Water (0.9% Benzyl Alcohol). This is not just a convenience but a necessity. The bacteriostatic agent inhibits bacterial growth in the reconstituted solution, allowing for multi-dose use over a period of time (typically up to 28 days when refrigerated) while maintaining sterility and peptide integrity.
GenLabs' Kisspeptin-5mg is intended for in vitro and preclinical research applications within controlled laboratory settings. Its primary research applications focus on:
Reproductive Endocrinology Research: As the key initiator of the HPG axis, Kisspeptin is a critical tool for studying pubertal development, gonadal steroid feedback mechanisms, and the pulsatile nature of gonadotropin secretion. Research investigates its role in conditions like hypogonadotropic hypogonadism.
Neuroendocrine Signaling Studies: Scientists utilize Kisspeptin to map and understand the complex neural circuits that control reproduction, including the interaction between metabolic signals (like leptin) and reproductive function.
Fertility-Related Investigations: Research explores the potential of Kisspeptin as a more physiological trigger for ovulation in assisted reproductive technology (ART) contexts, given its role in inducing endogenous GnRH/LH surges.
Metabolic and Reproductive Interface Studies: Given the link between energy balance and fertility, Kisspeptin serves as a primary research target for understanding how conditions like obesity or anorexia impact reproductive function.
Pharmacodynamic/Pharmacokinetic Studies: The GenLabs formulation is ideal for studies examining the half-life, bioavailability, and dose-response characteristics of Kisspeptin-10 administration.
Proper reconstitution is vital for maintaining peptide bioactivity and sterility.
Aseptic Technique: Perform all steps in a clean, laminar flow hood using sterile syringes, needles, and gloves.
Reconstitution: Gently inject the desired volume of the supplied bacteriostatic water (e.g., 1-2 mL) slowly down the side of the peptide vial to avoid aggressive agitation. Roll the vial gently between your hands until the lyophilized powder is fully dissolved. Do not shake vigorously, as this can cause peptide denaturation.
Storage: The reconstituted solution should be stored at 2-8°C (36-46°F) and used within the appropriate timeframe as dictated by laboratory sterility protocols. The lyophilized powder, unopened, should be stored in a cool, dry place, away from direct light.
Dosage Considerations: Research dosage is highly dependent on the specific model and study design. Researchers must determine appropriate concentrations based on existing scientific literature and pilot studies.
Integrated Research Solution: The inclusion of bacteriostatic water ensures you have everything needed to begin research immediately, prepared to the highest sterility standards.
Documented Purity: Access to a Certificate of Analysis (CoA) for your specific lot, detailing HPLC purity, mass spec confirmation, and sterility testing.
Manufacturing Transparency: GenLabs operates in cGMP-compliant facilities, ensuring traceability and consistency from synthesis to shipment.
Research Reliability: Consistent, high-quality peptide structure ensures reproducible results, reducing experimental variables and enhancing the credibility of your research outcomes.
Dedicated Support: Our commitment extends beyond the product. We provide comprehensive technical data sheets and support for qualified research professionals.
GenLabs Kisspeptin-5mg (with Bacteriostatic Water) is sold strictly for research and laboratory use only. It is classified as a Research Chemical. It is not intended for human or veterinary diagnostic, therapeutic, or any other clinical uses. It must not be introduced into food or drink products or household chemicals. The information contained herein is for educational and scientific reference purposes only.
Researchers assume full responsibility for handling this product in accordance with all applicable local, state, federal, and institutional guidelines and regulations. Proper personal protective equipment (PPE) must always be worn when handling.
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