The landscape of metabolic and endocrine research is perpetually evolving, driven by the pursuit of deeper understanding and more targeted interventions. At the forefront of this innovation stands a novel class of compounds with unprecedented mechanism of action. GENLABS is proud to introduce its high-purity, research-grade Retatrutide 5mg Vial, accompanied by Bacteriostatic Water, to the scientific community. This product represents not just a reagent, but a key to deciphering complex physiological pathways related to glucose homeostasis, energy expenditure, and weight regulation.
Disclaimer: Retatrutide is a potent, non-human, research-grade biochemical compound. It is intended solely for in vitro laboratory research and analysis by qualified professionals in controlled scientific environments. This product is not for human or veterinary use, nor is it a drug, dietary supplement, or cosmetic. It must not be introduced into any living organism. Researchers are solely responsible for ensuring compliance with all local, state, and federal regulations regarding the handling, storage, and disposal of research peptides.
Retatrutide (also known by its research code LY3437943) is a single peptide molecule engineered to simultaneously activate three distinct metabolic receptors: the Glucagon-like peptide-1 (GLP-1), Glucose-dependent insulinotropic polypeptide (GIP), and Glucagon receptors. This "triple-agonist" profile marks a significant advancement over single- or dual-receptor agonists, offering researchers a unique tool to study the synergistic effects of these interconnected hormonal pathways.
GLP-1 Receptor Agonism: A well-researched pathway known to enhance glucose-dependent insulin secretion, suppress glucagon release, delay gastric emptying, and promote satiety signals in the central nervous system.
GIP Receptor Agonism: This pathway complements GLP-1 by further stimulating insulin secretion in a glucose-dependent manner and may influence lipid metabolism and bone biology. Research suggests GIP receptor activation could modulate the effects of GLP-1, offering a broader metabolic impact.
Glucagon Receptor Agonism: This is the differentiating factor. While glucagon traditionally raises blood glucose, its strategic activation alongside incretin hormones (GLP-1 and GIP) is hypothesized to profoundly increase energy expenditure, enhance lipolysis (fat breakdown), and improve hepatic (liver) fat metabolism.
The research hypothesis centers on this combination creating a powerful, integrated metabolic effect: enhanced glycemic control coupled with significant promotion of energy expenditure. For researchers, GENLABS Retatrutide provides the critical material to test this hypothesis in controlled in vitro models, exploring cellular responses, receptor signaling cascades, and gene expression profiles.
In research, outcomes are only as credible as the inputs. GENLABS formulates its Retatrutide 5mg Vial to meet the exacting standards required for reproducible, high-impact science.
Exceptional Purity (>99%): Our Retatrutide is synthesized using advanced solid-phase peptide synthesis (SPPS) and undergoes rigorous purification via High-Performance Liquid Chromatography (HPLC). Each batch is accompanied by Mass Spectrometry (MS) analysis, providing documented, third-party-verified proof of identity and purity. This minimizes the variable of impurities, ensuring that observed cellular effects are attributable to Retatrutide itself.
Precise Lyophilized Format: The peptide is provided as a sterile, lyophilized (freeze-dried) white powder in a sealed, neutral glass vial. The lyophilization process ensures long-term stability and protects the structural integrity of the molecule during transport and storage.
Included Bacteriostatic Water: We supply a separate 1mL vial of Bacteriostatic Water (0.9% Benzyl Alcohol). This sterile solvent is essential for the proper reconstitution of the peptide. The bacteriostatic agent inhibits microbial growth in the solution after opening, maintaining sterility for the duration of multi-use in vitro protocols over a short period. Important Reconstitution Note: Researchers must use proper aseptic technique. The addition of the solvent should be gentle, directed down the side of the vial to avoid aggressive agitation that could stress the peptide. The resulting solution should be clear and colorless.
Molecular Formula: C₂₅₄H₃₉₈N₇₂O₇₈S
Molecular Weight: Approximately 5851.5 Da
Sequence: [Research-grade peptide sequence, 39 amino acids]
Purity: ≥99% verified by HPLC and MS
Presentation: 5mg lyophilized peptide in sterile vial + 1mL vial of Bacteriostatic Water.
Storage: Store the unreconstituted vial in a freezer at or below -20°C. Protect from light. Post-reconstitution, the solution should be used immediately in accordance with proper laboratory practice for in vitro use. Do not freeze reconstituted solution.
Potential Research Applications Include:
Mechanistic Metabolic Studies: Investigating the integrated signaling of GLP-1R, GIPR, and GCGR in cultured hepatocytes, adipocytes, or pancreatic cell lines.
Gene Expression Analysis: Assessing up- or down-regulation of genes related to thermogenesis (e.g., UCP1), lipogenesis, gluconeogenesis, and insulin sensitivity in tissue models.
Receptor Binding & Activation Assays: Quantifying affinity (Kd) and efficacy (EC50) at each target receptor in comparative studies.
Synergistic Effect Modeling: Developing in vitro models to understand how the three agonist activities interact, potentially revealing new therapeutic targets for metabolic disorders.
Safety Pharmacology Screening: Preliminary assessment of cellular tolerance and response profiles in specialized assays.
Focus on Research: GENLABS is dedicated exclusively to serving the scientific community. Our products, including this Retatrutide, are developed with research applications as the sole focus.
Documentation & Transparency: We provide comprehensive Certificates of Analysis (CoA) for traceability and verification, empowering researchers to validate their materials.
Stability & Consistency: Our stringent manufacturing and packaging protocols ensure you receive a stable, potent product, batch after batch, which is fundamental for longitudinal studies.
Responsible Supply: We adhere to all applicable laws and supply only to legitimate research institutions and qualified professionals.
Retatrutide is a potent compound requiring the highest level of respect and caution.
Personal Protective Equipment (PPE): Always wear a lab coat, gloves, and safety glasses when handling.
Aseptic Technique: Reconstitution and any aliquot preparation must be performed in a laminar flow hood using sterile syringes and vials to prevent contamination.
Disposal: Dispose of all materials (vials, sharps, etc.) in accordance with institutional biohazard and chemical waste protocols.
GENLABS Retatrutide 5mg Vial is available for purchase through our secure portal. Verification of institutional affiliation or professional research status may be required.
In Conclusion:
The GENLABS Retatrutide 5mg Vial (with Bacteriostatic Water) is more than a product—it is a dedicated research tool designed to facilitate groundbreaking discoveries in metabolism. By offering this high-purity triple-agonist, we empower scientists to explore the complex crosstalk between crucial hormonal pathways with precision and confidence. Choose GENLABS for purity you can trust and a partnership dedicated to the advancement of science.
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