Product Name: GenLabs Semaglutide – 5mg/Vial (with Bacteriostatic Water)
CAS Number: 910463-68-2
Molecular Formula: C₁₈₇H₂₉₁N₄₅O₅₉
Sequence: H-His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(Boc)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH
Purity: ≥99% (as determined by HPLC)
Presentation: Lyophilized powder in a sterile, sealed vial. Packaged with 1x 5mg Semaglutide vial and 1x 30ml vial of Bacteriostatic Water (0.9% Benzyl Alcohol).
In the rigorous field of metabolic and endocrine research, the quest for high-purity, reliable tools is paramount. GenLabs introduces its professional-grade Semaglutide 5mg/Vial, a meticulously synthesized glucagon-like peptide-1 (GLP-1) receptor agonist, provided as a lyophilized powder for research use only. This product, accompanied by a dedicated vial of bacteriostatic water for reconstitution, is engineered for scientists and research institutions requiring uncompromised quality and consistency in their preclinical studies. Semaglutide’s unique pharmacological profile, characterized by its extended half-life and potent receptor affinity, makes it an indispensable compound for investigating pathways related to glucose homeostasis, appetite regulation, and weight management mechanisms.
GenLabs Semaglutide is manufactured in an ISO-certified facility under strict sterile conditions. Every batch is subjected to rigorous third-party analytical testing, including High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS), to confirm a purity level of 99% or higher and verify peptide sequence accuracy. This commitment to quality ensures researchers can trust the integrity of their compound, eliminating variability and uncertainty from their experimental results.
Semaglutide is a long-acting, acylated analog of human GLP-1, a naturally occurring incretin hormone that potentiates glucose-dependent insulin secretion. Its molecular design incorporates key modifications that confer profound stability and extended activity:
Amino Acid Substitution at Position 8: The substitution of Alanine with the non-proteinogenic AminoIsobutyric Acid (Aib) at position 8 provides exceptional resistance to degradation by the ubiquitous enzyme Dipeptidyl Peptidase-4 (DPP-4). This is the first critical modification that drastically extends the peptide's plasma half-life beyond that of native GLP-1.
C-18 Fatty Diacid Chain Modification: A strategic attachment of a spacer and a C-18 fatty diacid chain to Lysine at position 26 enables strong, reversible binding to serum albumin. This allows Semaglutide to circulate in the bloodstream for an extended duration while protecting it from renal clearance.
Potent GLP-1 Receptor Agonism: These structural enhancements not only prolong activity but also enhance affinity for the GLP-1 receptor. The result is a research compound with a pronounced and sustained effect on receptor signaling pathways, making it highly suitable for chronic study models requiring less frequent dosing interventions.
Primary Research Applications & Mechanisms of Action:
In a controlled research setting, GenLabs Semaglutide facilitates the study of:
Glucose-Dependent Insulin Secretion: Semaglutide potentiates the secretion of insulin from pancreatic beta-cells in a strictly glucose-concentration-dependent manner. This minimizes the risk of hypoglycemia in research models, a key area of investigation for diabetic pathology.
Suppression of Glucagon Secretion: It inhibits the release of glucagon from pancreatic alpha-cells, particularly in hyperglycemic states, thereby reducing hepatic glucose output.
Gastric Emptying Delay: Semaglutide slows gastric emptying, which contributes to a moderated postprandial glycemic rise and influences satiety signaling.
Central Appetite Regulation: A critical area of research is Semaglutide's action on GLP-1 receptors in the hypothalamus and brainstem. Activation of these central pathways promotes satiety, reduces food intake, and is a focal point for obesity-related research.
Beta-Cell Preservation & Function: Preclinical studies utilize Semaglutide to investigate its potential effects on beta-cell proliferation, neogenesis, and the inhibition of apoptosis.
Choosing GenLabs Semaglutide means selecting a partner dedicated to scientific integrity.
Unmatched Purity & Verification: Our ≥99% purity guarantee is not a claim but a verified result. Each vial ships with a comprehensive Certificate of Analysis (CoA) detailing HPLC chromatograms and MS data, ensuring complete traceability and transparency.
Sterile, Lyophilized Presentation: The peptide is supplied as a sterile, lyophilized (freeze-dried) powder in a sealed, neutral glass vial. This format ensures long-term stability when stored correctly and allows for precise, flexible reconstitution to meet various experimental dosing protocols.
Included Bacteriostatic Water: We provide a complimentary 30ml vial of USP-grade Bacteriostatic Water (containing 0.9% Benzyl Alcohol). This sterile solvent is specifically designed for multi-dose peptide reconstitution, inhibiting bacterial growth for up to 28 days post-puncture when refrigerated, offering convenience and reducing waste.
Stability & Storage: For optimal long-term stability, store the lyophilized powder at or below -20°C. Once reconstituted with the provided bacteriostatic water, the solution must be stored refrigerated at 2-8°C and used within a defined period as per your laboratory's sterile protocols.
Important Note: The following is a general guideline. Researchers must determine the appropriate solvent, concentration, and dosage for their specific in vitro or in vivo study protocols.
Aseptic Technique: Perform all steps in a sterile laminar flow hood using sterilized syringes, needles, and personal protective equipment.
Reconstitution: Gently inject the desired volume of the provided bacteriostatic water (e.g., 2ml) slowly down the side of the Semaglutide vial to avoid aggressive agitation of the peptide cake.
Gentle Mixing: Roll the vial gently between your palms until the lyophilized powder is fully dissolved. Do not shake vigorously, as this can cause denaturation and fibrillation of the peptide.
Calculation: Example: Adding 2ml of bacteriostatic water to a 5mg vial yields a concentration of 2.5mg/ml (or 2500 mcg/ml). Researchers can then calculate precise volumetric doses for administration.
CRITICAL NOTICE: GENLABS PRODUCTS ARE INTENDED FOR RESEARCH USE ONLY (RUO).
GenLabs Semaglutide 5mg/Vial is a laboratory chemical for in vitro or preclinical research applications by qualified professionals in controlled settings. It is not for human or veterinary diagnostic, therapeutic, or any other clinical use. It must not be introduced into food, drugs, or household products. The purchaser assumes all responsibility for handling, storage, and disposal in compliance with their institution's guidelines and all applicable local, state, and federal regulations.
By providing a research compound of exceptional purity paired with essential reconstitution solutions, GenLabs empowers the scientific community to push the boundaries of metabolic understanding with confidence and precision. Choose GenLabs Semaglutide for your next research endeavor—where quality is synthesized, and discovery is catalyzed.
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