BOTULINUM TOXIN TYPE A PH. EUR., globally recognized under the brand name BOTOX® 100 Units from Allergan Aesthetics, an AbbVie company, represents a landmark achievement in medical science and aesthetic medicine. It is not merely a product; it is a precisely engineered, highly purified pharmaceutical agent that has revolutionized treatment paradigms across multiple therapeutic areas. Manufactured under the stringent specifications of the European Pharmacopoeia (Ph. Eur.), this formulation assures healthcare professionals and patients of unparalleled quality, consistency, and safety. Each vial contains 100 units of Clostridium botulinum type A neurotoxin complex, a potency meticulously calibrated for predictable, reliable, and effective results. As the original and most extensively researched neuromodulator, BOTOX® 100U stands as the gold standard against which all others are measured, backed by decades of clinical data, peer-reviewed studies, and real-world application.
The profound efficacy of BOTOX® is rooted in its sophisticated, targeted mechanism of action. At its core, Botulinum Toxin Type A is a neuro-modulatory protein that acts with exquisite precision at the presynaptic membrane of cholinergic nerve terminals. It specifically and temporarily inhibits the release of the neurotransmitter acetylcholine.
Targeted Binding & Internalization: The molecule binds selectively to receptors on the nerve endings of neuromuscular junctions or autonomic cholinergic neurons.
Cleavage of SNAP-25: Once internalized, the light chain of the toxin acts as a protease, cleaving the SNAP-25 protein. This protein is an essential component of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex.
Inhibition of Neurotransmitter Release: The cleavage of SNAP-25 disrupts the SNARE complex assembly. This prevents the vesicle containing acetylcholine from fusing with the presynaptic membrane, thereby blocking its release into the synaptic cleft.
Temporary & Localized Effect: This inhibition is temporary and localized strictly to the injection site. Over a period of approximately 3 to 4 months, the body initiates a process of neuronal repair, involving the sprouting of new nerve terminals and the restoration of the original SNARE complex proteins, leading to a gradual return of neuromuscular function.
This science translates directly into clinical benefit: the targeted relaxation of hyperactive muscles or the temporary reduction of glandular activity, depending on the treatment area.
BOTOX® 100U is a multi-indication product with a broad scope of use, testament to its versatility and therapeutic value.
Aesthetic Medicine (Glabellar Lines):
Primary Use: The temporary improvement in the appearance of moderate to severe glabellar lines (vertical frown lines between the eyebrows) associated with corrugator and/or procerus muscle activity in adult patients.
Outcome: Creates a smoother, more relaxed, and refreshed facial appearance without affecting the natural expressiveness of the rest of the face when administered by a skilled practitioner.
Therapeutic Neurology & Medicine:
Management of Muscle Spasticity: Treatment of upper limb spasticity in adult patients, and lower limb spasticity in pediatric patients (2 years+), helping to reduce muscle stiffness and improve mobility and care.
Chronic Migraine Prophylaxis: For the prophylaxis of headaches in adult patients with Chronic Migraine (≥15 headache days per month with headache lasting 4+ hours), significantly reducing the number of headache days.
Blepharospasm & Strabismus: Treatment of abnormal contractions of the eyelid muscles (blepharospasm) and misalignment of the eyes (strabismus) in patients 12 years and older.
Severe Axillary Hyperhidrosis: Management of excessive sweating inadequately managed by topical agents in patients 18 years+, by blocking acetylcholine stimulation of eccrine sweat glands.
Neurogenic Detrusor Overactivity & Overactive Bladder: Treatment of urinary incontinence in adult patients with neurogenic detrusor overactivity or Overactive Bladder symptoms (urgency, frequency, urge incontinence).
Spasticity in Pediatric Cerebral Palsy: A vital tool for managing lower limb spasticity in children with cerebral palsy, aiding in gait and functional improvement.
Choosing BOTOX® 100U is a choice for uncompromising quality.
Ph. Eur. Standard: The "Ph. Eur." designation signifies it is manufactured to meet the exacting monographs of the European Pharmacopoeia, ensuring identity, potency, purity, and consistency that comply with the highest European regulatory benchmarks.
Stringent Manufacturing: Allergan’s proprietary manufacturing process yields a highly purified formulation with a precisely defined 900kD molecular weight neurotoxin complex. This consistent molecular profile is key to its predictable diffusion characteristics and reliable clinical performance.
Extensive Research Portfolio: With over 30 years of clinical study, more than 2,700 peer-reviewed publications, and ongoing pharmacovigilance, BOTOX® has a safety and efficacy profile that is intimately understood by the global medical community.
Reconstitution & Handling: The product is supplied as a sterile, vacuum-dried powder requiring reconstitution with sterile, preservative-free 0.9% sodium chloride before use. Strict adherence to recommended storage, preparation, and injection techniques is paramount to maintain sterility and potency.
BOTOX® is a potent prescription medicine. Its use requires thorough medical evaluation by a qualified healthcare professional.
Common Side Effects: Are typically mild, transient, and localized to the injection site (e.g., pain, swelling, erythema, bruising). Site-specific effects may include headache, neck pain, eyelid ptosis (in aesthetic use), or dry mouth.
Serious Risks: Distant spread of toxin effect from the injection site can occur, leading to symptoms consistent with botulism (e.g., muscle weakness, dysphagia, aspiration pneumonia, dysphonia). This risk may be increased in patients with underlying neurological disorders.
Absolute Contraindications: Include known hypersensitivity to any botulinum toxin preparation or excipients in the formulation, or the presence of infection at the proposed injection site(s).
Critical Warnings: BOTOX® is contraindicated in patients with myasthenia gravis, Eaton-Lambert syndrome, or other significant pre-existing neuromuscular disorders. Extreme caution is required when there is an anatomical abnormality or marked weakness/atrophy in the target muscle.
BOTULINUM TOXIN TYPE A PH. EUR. – BOTOX® 100UNITS – ALLERGAN HEALTHCARE is far more than a commodity. It is a foundational tool in modern therapeutic and aesthetic practice. Its legacy of innovation, its bedrock of scientific evidence, and its unwavering commitment to quality under the Ph. Eur. standard make it the first-choice neuromodulator for discerning healthcare providers worldwide. For practices dedicated to delivering predictable, safe, and evidence-based outcomes—whether to alleviate debilitating medical conditions or to meet aesthetic goals—BOTOX® 100U remains the benchmark of excellence and the most trusted name in neurotoxin therapy.
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Owen Reed
The customer service was exceptional. They were helpful and responsive throughout the entire process.
Owen Reed
The customer service was exceptional. They were helpful and responsive throughout the entire process.
Carter Reed
The customer service was exceptional. They were helpful and responsive throughout the entire process.