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CLOMID CLOMIPHENE CITRATE 50 MG PER TAB

Description for CLOMID CLOMIPHENE CITRATE 50 MG PER TAB

CLOMID (CLOMIPHENE CITRATE) 50MG – A Cornerstone of Fertility Therapy by GenLabs

For millions of individuals and couples navigating the challenging journey of infertility, the name Clomid (Clomiphene Citrate) stands as a beacon of hope and a first-line therapeutic intervention. GenLabs, a reputable pharmaceutical manufacturer, presents its high-quality formulation: Clomid (Clomiphene Citrate) 50mg per tablet, in a convenient pack of 100 tablets. This oral medication is a proven, well-researched, and widely prescribed agent primarily used to stimulate ovulation in women who experience ovulatory dysfunction. This comprehensive product description delves into the science, applications, proper usage, and essential considerations surrounding this pivotal fertility drug.

Understanding the Science: How Does Clomid (Clomiphene Citrate) Work?

Clomid’s efficacy lies in its sophisticated mechanism of action as a Selective Estrogen Receptor Modulator (SERM). To understand its role in fertility, one must first grasp the hormonal dialogue between the brain and the ovaries.

In a regular menstrual cycle, the hypothalamus in the brain releases Gonadotropin-Releasing Hormone (GnRH), which signals the pituitary gland to secrete Follicle-Stimulating Hormone (FSH) and Luteinizing Hormone (LH). These hormones are the direct catalysts for ovarian follicle growth and ovulation. Estrogen, produced by the developing follicles, provides negative feedback to the pituitary, regulating this system.

In conditions like polycystic ovary syndrome (PCOS) or other anovulatory disorders, this feedback loop is often imbalanced. Clomiphene Citrate intervenes by competitively binding to estrogen receptors in the hypothalamus. This blocks the brain from detecting the body's circulating estrogen. Misperceiving a state of low estrogen, the hypothalamus and pituitary gland respond by significantly increasing the secretion of GnRH, FSH, and LH. This heightened gonadotropin surge effectively "jump-starts" the ovaries, promoting the recruitment, maturation, and eventual release of a mature egg (ovulation). It is crucial to note that Clomid does not create new eggs; it stimulates the ovaries to utilize the existing follicle pool.

Primary Indications and Clinical Use

GenLabs Clomid 50mg is a prescription-only medication intended for specific fertility-related diagnoses:

  1. Ovulation Induction in Anovulatory Women: This is the primary and most common use. It is the treatment of choice for women who do not ovulate regularly (anovulation) or at all, particularly those diagnosed with PCOS. By restoring regular ovulation, it significantly increases the probability of conception.

  2. Unexplained Infertility: Clomid may be used empirically in couples with unexplained infertility to enhance fertility potential by ensuring timed ovulation, often combined with intrauterine insemination (IUI).

  3. Male Infertility (Off-label): Although not its primary indication, Clomid is sometimes prescribed off-label to treat certain cases of male infertility, such as hypogonadotropic hypogonadism. In men, it can help increase endogenous testosterone and, in some cases, improve sperm parameters by stimulating the pituitary-gonadal axis.

  4. Assessment of Ovarian Reserve: The Clomiphene Citrate Challenge Test (CCCT) is a diagnostic tool where a woman’s FSH levels are measured before and after a course of Clomid. It helps assess ovarian reserve and response.

Dosage, Administration, and Treatment Cycle

The GenLabs 100-tablet pack provides a full and flexible treatment supply. Self-medication is strictly prohibited. Dosage must be meticulously determined and monitored by a qualified fertility specialist or gynecologist.

  • Standard Dosage: Treatment typically begins with a 50mg (one tablet) dose once daily for five days, usually starting on day 3, 4, or 5 of the menstrual cycle (with day 1 being the first day of menstrual bleeding).

  • Monitoring: Physicians often employ monitoring tools such as transvaginal ultrasounds to track follicular growth and blood tests to check hormone levels. This ensures optimal timing for intercourse or IUI and minimizes risks like multiple pregnancies.

  • Dosage Adjustment: If ovulation does not occur at the 50mg dose, the physician may increase the dose in subsequent cycles to 100mg (two tablets) daily for five days. The maximum recommended daily dose is 150mg. The 100-tablet pack accommodates these dose adjustments across multiple treatment cycles.

  • Treatment Duration: Clomid therapy is usually recommended for 3 to 6 ovulatory cycles. If pregnancy is not achieved within this timeframe, a re-evaluation and consideration of advanced fertility treatments are advised.

Potential Side Effects and Important Safety Considerations

While Clomid is generally well-tolerated, patients should be aware of potential side effects, which are usually mild and dose-dependent.

  • Common Side Effects: These may include hot flashes (the most frequently reported), mood swings, breast tenderness, abdominal bloating, nausea, headaches, and visual disturbances (such as blurring or spots). Visual symptoms, though rare, warrant immediate discontinuation and physician consultation.

  • Serious Risks:

    • Ovarian Hyperstimulation Syndrome (OHSS): A rare but serious condition where ovaries become swollen and painful. Symptoms include severe pelvic pain, rapid weight gain, abdominal distension, nausea, and shortness of breath.

    • Multiple Pregnancies: The chance of twins with Clomid is approximately 5-10%. The risk of triplets or more is significantly lower (<1%) but present.

    • Cervical Mucus & Endometrial Lining: Clomid’s anti-estrogenic effects can sometimes lead to thickened cervical mucus (impeding sperm passage) or a thin endometrial lining. Your doctor will monitor for these.

    • Ectopic Pregnancy: A slightly increased risk exists.

  • Contraindications: Clomid is contraindicated in pregnancy, liver disease, abnormal uterine bleeding of undetermined cause, ovarian cysts unrelated to PCOS, and in patients with uncontrolled thyroid or adrenal disorders.

Why Choose GenLabs Clomid 50mg Tablets?

  1. Proven Efficacy & Trust: Clomiphene Citrate has over 60 years of clinical history, making it one of the most studied and trusted first-line fertility treatments globally.

  2. GenLabs Quality Assurance: This product is manufactured under stringent Good Manufacturing Practice (GMP) conditions, ensuring consistent dosage, purity, and pharmaceutical integrity in every 50mg tablet.

  3. Cost-Effective Therapy: Compared to injectable gonadotropins, Clomid remains a significantly more affordable oral option for ovulation induction.

  4. Convenience: The 100-tablet package offers an ample supply for multiple treatment cycles as directed by a physician, providing convenience and continuity of care.

Final Patient Guidance

GenLabs Clomid (Clomiphene Citrate) 50mg is a powerful prescription pharmaceutical, not a dietary supplement. It is a fundamental tool in reproductive medicine that has helped countless individuals achieve their dream of parenthood. Success hinges on a partnership between a patient and a skilled reproductive endocrinologist who can provide proper diagnosis, personalized dosing, and crucial cycle monitoring.

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    • Purity & Quality: Manufactured by GENLABS under strict sterile conditions, utilizing advanced peptide synthesis for >99% purity, verified by HPLC analysis.

    • Presentation: Lyophilized (freeze-dried) powder in a sterile, sealed multi-dose vial for stability and longevity.

    • Included Convenience: Each vial is paired with a dedicated 1ml ampule of Bacteriostatic Water (0.9% Benzyl Alcohol). This eliminates the need for separate sourcing, ensures compatibility, and allows for precise, multi-dose reconstitution while maintaining sterility.

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    • Stability & Potency Guarantee: The lyophilized powder format ensures long-term stability. When reconstituted correctly with the provided bacteriostatic water and stored refrigerated, the solution maintains its potency for the duration of its use.

    • Researcher-Focused Design: We understand the needs of the scientific community. The inclusion of bacteriostatic water, clear vial labeling, and detailed documentation reflect our dedication to facilitating professional-grade research.

    • Safety & Sterility: Vials are filled and capped in a sterile environment, mitigating any risk of contamination or endotoxin presence, which is a common concern with inferior products.

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    1. Reconstitution: Gently inject 1ml of the provided Bacteriostatic Water into the 5mg Hexarelin vial. Aim the stream against the glass wall to avoid aggressive agitation. Roll gently between palms until the powder is fully dissolved. DO NOT SHAKE.

    2. Dosage in Research Models: In animal research models, common effective doses for studying GH release often range from 1-2 mcg per kg of body weight, administered 1-3 times per day. The 5mg vial allows for precise dosing flexibility. A starting dose for research is typically at the lower end of this range to assess individual response.

    3. Administration: The reconstituted solution is typically administered via subcutaneous (SC) injection in research settings. All procedures must adhere to strict sterile technique.

    4. Storage: Store the unmixed vial in a cool, dark place (refrigeration is optimal). After reconstitution, the solution must be refrigerated and used within a set period (typically 14-21 days) due to the preservative in the bacteriostatic water.

    Tolerance and Research Considerations

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    • Hypokalemia: Insulin, including Lantus, can cause low potassium levels, which may be serious.

    • Fluid Retention & Heart Failure: May occur with concomitant use of TZDs (thiazolidinediones).

    • Administration: For subcutaneous injection onlyDo not administer intravenously or via an insulin pump. Rotate injection sites within the same region (abdomen, thigh, or upper arm) to reduce the risk of lipodystrophy.

    • Drug Interactions: Certain drugs may affect insulin requirements. Close monitoring is required when starting or stopping any medication.

    Common Side Effects: Hypoglycemia, allergic reactions, injection site reactions (redness, swelling, itching), lipodystrophy, itching, rash, and weight gain.

    Who Should Not Use Lantus? Patients experiencing hypoglycemia or with a hypersensitivity to insulin glargine or any excipients.


    Directions for Use: A Step-by-Step Guide

    1. Preparation: Wash hands. Check the pen label to ensure it is Lantus and not expired. Attach a new pen needle. Perform a "safety test" (prime) by dialing 2 units, pointing the pen upward, and pressing the injection button until a drop of insulin appears at the needle tip.

    2. Dose Selection: Dial the exact number of units prescribed by your healthcare provider.

    3. Injection: Insert the needle into your chosen, clean injection site at a 90-degree angle. Press the injection button down fully and hold. Slowly count to 10 before withdrawing the needle to ensure the full dose is delivered.

    4. Disposal: Safely remove the needle using the outer cap and discard in an FDA-cleared sharps container. Do not store the pen with the needle attached, as this can lead to leakage, contamination, or air bubbles. Store the pen without the needle attached.

    Storage:

    • Unopened (Refrigerated): Store at 36°F to 46°F (2°C to 8°C). Do not freeze. Keep away from the cooling element.

    • In-Use: Once punctured with a needle, the pen can be kept at room temperature (below 86°F or 30°C) for up to 28 days. Do not refrigerate the pen you are currently using. Protect from direct heat and light. Discard after 28 days, even if insulin remains.


    Why Choose LANTUS SOLOSTAR?

    LANTUS SOLOSTAR represents a trusted, evidence-based choice in basal insulin therapy. Its proven efficacy in providing consistent 24-hour coverage, combined with the ergonomic and intuitive SoloStar delivery system, supports patients in achieving their glycemic targets. The inclusion of pen needles in this offering underscores a commitment to a complete patient experience, removing a potential barrier to proper injection technique and therapy initiation.

    For over two decades, Lantus has been a foundational therapy for millions of patients worldwide, backed by Sanofi's extensive research and support programs. It is a critical tool in the diabetes management plan, working to reduce the risk of long-term complications associated with uncontrolled blood sugar.



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