LANTUS SOLOSTAR® is a high-quality, long-acting basal insulin analog designed to provide foundational blood sugar control for adult and pediatric patients (6 years and older) with type 1 diabetes and for adults with type 2 diabetes. Manufactured by Sanofi, a global leader in diabetes care, this product includes a state-of-the-art, disposable prefilled insulin pen (SoloStar) and a box of compatible pen needles for easy, precise, and comfortable administration. Each LANTUS SOLOSTAR pen contains 3 mL of insulin glargine at a concentration of 100 units per mL (U-100), offering a consistent and prolonged release of insulin to mimic the body's natural basal insulin secretion.
LANTUS® (insulin glargine) is indicated to improve glycemic control. In type 1 diabetes, it is used alongside mealtime (bolus) insulin. In type 2 diabetes, it may be used alone or combined with oral anti-diabetic medications or other injectable therapies.
Its unique mechanism stems from a slight modification to the human insulin molecule, making it less soluble at physiological pH. After subcutaneous injection, the solution forms a micro-precipitate, allowing for a slow, steady, and predictable release of insulin glargine into the bloodstream. This action profile results in a relatively constant concentration/time profile with no pronounced peak, providing up to 24 hours of basal insulin coverage. This helps manage fasting blood glucose (FBG) and blood sugar levels between meals and overnight, forming the critical "basal" layer of diabetes management.
LANTUS is engineered for a prolonged duration of action, offering a flat and stable pharmacokinetic profile. This consistency helps patients achieve lower and more predictable fasting blood glucose levels, which is a cornerstone of overall glycemic management as measured by A1C.
Sanofi's SoloStar pen is widely recognized for its patient-friendly design, enhancing adherence and injection confidence.
Dose Accuracy: Delivers precise doses in 1-unit increments up to a maximum of 80 units per injection.
Easy Dose Setting: A large, easy-to-grip dial and clear, digital dose window (especially beneficial for users with visual or dexterity challenges) make dose selection straightforward.
Smooth Injection: Requires low injection force. An audible "click" confirms each unit dialed and a distinct sound confirms the full dose has been delivered.
End-of-Dose Indicator: Clearly shows the remaining insulin in the pen, preventing surprises.
Discreet and Portable: The slim, lightweight design is easy to carry and use discreetly.
This offering includes a box of compatible pen needles, ensuring patients have everything needed to begin therapy immediately. It is crucial to use a new needle for every injection to ensure sterility, prevent contamination, reduce pain, and maintain dose accuracy. Needles are not included with the pen itself and must be purchased separately; this bundle provides convenience and peace of mind.
LANTUS SOLOSTAR offers dosing versatility. It is typically administered once daily at the same time each day. The time of administration can be adjusted to fit individual patient lifestyles, provided it is consistent daily. Dose adjustments should always be made under the guidance of a healthcare professional based on blood glucose monitoring patterns.
BOXED WARNING: RISK OF HYPOGLYCEMIA, AND DO NOT DILUTE OR MIX WITH OTHER INSULINS.
Hypoglycemia (low blood sugar) is the most common adverse reaction. It can be severe and life-threatening, causing seizures, loss of consciousness, or death. Risk increases with intensive glycemic control, changes in meal patterns, physical activity, and concomitant use of other anti-diabetic drugs. Careful monitoring and patient education on recognition and treatment are essential.
LANTUS MUST NOT BE DILUTED OR MIXED with any other insulin or solution. Mixing can alter its time-action profile and cause precipitation.
Additional Warnings & Precautions:
Hypersensitivity Reactions: Severe, life-threatening allergy is possible. Discontinue use if reactions occur.
Hypokalemia: Insulin, including Lantus, can cause low potassium levels, which may be serious.
Fluid Retention & Heart Failure: May occur with concomitant use of TZDs (thiazolidinediones).
Administration: For subcutaneous injection only. Do not administer intravenously or via an insulin pump. Rotate injection sites within the same region (abdomen, thigh, or upper arm) to reduce the risk of lipodystrophy.
Drug Interactions: Certain drugs may affect insulin requirements. Close monitoring is required when starting or stopping any medication.
Common Side Effects: Hypoglycemia, allergic reactions, injection site reactions (redness, swelling, itching), lipodystrophy, itching, rash, and weight gain.
Who Should Not Use Lantus? Patients experiencing hypoglycemia or with a hypersensitivity to insulin glargine or any excipients.
Preparation: Wash hands. Check the pen label to ensure it is Lantus and not expired. Attach a new pen needle. Perform a "safety test" (prime) by dialing 2 units, pointing the pen upward, and pressing the injection button until a drop of insulin appears at the needle tip.
Dose Selection: Dial the exact number of units prescribed by your healthcare provider.
Injection: Insert the needle into your chosen, clean injection site at a 90-degree angle. Press the injection button down fully and hold. Slowly count to 10 before withdrawing the needle to ensure the full dose is delivered.
Disposal: Safely remove the needle using the outer cap and discard in an FDA-cleared sharps container. Do not store the pen with the needle attached, as this can lead to leakage, contamination, or air bubbles. Store the pen without the needle attached.
Storage:
Unopened (Refrigerated): Store at 36°F to 46°F (2°C to 8°C). Do not freeze. Keep away from the cooling element.
In-Use: Once punctured with a needle, the pen can be kept at room temperature (below 86°F or 30°C) for up to 28 days. Do not refrigerate the pen you are currently using. Protect from direct heat and light. Discard after 28 days, even if insulin remains.
LANTUS SOLOSTAR represents a trusted, evidence-based choice in basal insulin therapy. Its proven efficacy in providing consistent 24-hour coverage, combined with the ergonomic and intuitive SoloStar delivery system, supports patients in achieving their glycemic targets. The inclusion of pen needles in this offering underscores a commitment to a complete patient experience, removing a potential barrier to proper injection technique and therapy initiation.
For over two decades, Lantus has been a foundational therapy for millions of patients worldwide, backed by Sanofi's extensive research and support programs. It is a critical tool in the diabetes management plan, working to reduce the risk of long-term complications associated with uncontrolled blood sugar.
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Ethan Miller
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