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FOXO4 DRI 10MG WITH BACTERIOSTATIC WATER

Description for FOXO4 DRI 10MG WITH BACTERIOSTATIC WATER

GENLABS FOXO4-DRI 10mg (with Bacteriostatic Water) | A High-Purity Research Peptide for Cellular Senescence Studies

Product Name: GENLABS FOXO4-DRI 10mg Research Peptide Kit (Including 1x 10mg FOXO4-DRI Lyophilized Powder & 1x 10ml Bacteriostatic Water)
CAS Number: [To be filled by GENLABS - e.g., 2212441-64-0]
Molecular Formula: Câ‚₈₇H₃â‚â‚€N₅₆O₅₃S
Sequence: D-Y-R-K-L-L-Q-K-R-K-R-Q-Q-R-R-P-P-S-C*
Purity: ≥98% (as verified by HPLC-MS)
Storage: Store lyophilized powder at -20°C or below. Reconstituted solution should be stored at 2-8°C and used within a specified research timeframe.

Introduction: Targeting the Pivotal Senescence Pathway

In the advancing field of biogerontology and cellular biology, the study of cellular senescence represents a cornerstone for understanding age-related physiological decline. Senescent cells, characterized by their irreversible cell cycle arrest and the secretion of pro-inflammatory factors (the Senescence-Associated Secretory Phenotype, SASP), accumulate with age and contribute significantly to tissue dysfunction. GENLABS introduces FOXO4-DRI 10mg, a highly specific, research-grade peptide designed to disrupt a key protein-protein interaction involved in senescence maintenance. This product, provided as a complete kit with bacteriostatic water, offers scientists a precise and reliable tool for in vitro and pre-clinical investigation into senolytic strategies—the selective clearance of senescent cells.

Mechanism of Action: A Disruptor of the FOXO4-p53 Interaction

FOXO4-DRI (FOXO4-D-Retro-Inverso) is a rationally designed, cell-permeable peptide with a novel retro-inverso structure. This design confers enhanced stability and bioavailability in biological systems compared to its linear counterpart. Its primary target is the forkhead box O4 (FOXO4) transcription factor and its interaction with the tumor suppressor protein p53.

In senescent cells, p53 is typically sequestered in the nucleus by FOXO4. This interaction is a critical mechanism that prevents p53 from initiating apoptosis (programmed cell death) in the senescent cell. FOXO4-DRI functions as a competitive inhibitor:

  1. Specific Binding: The peptide's structure mimics the domain on FOXO4 that binds to p53.

  2. Displacement: By binding with high affinity to p53, FOXO4-DRI displaces FOXO4, breaking the inhibitory complex.

  3. p53 Activation & Apoptosis: Once freed from FOXO4, p53 can migrate to the mitochondria and initiate the intrinsic apoptotic pathway, leading to the selective elimination of the senescent cell.

  4. Selectivity: This mechanism is preferentially active in cells where the FOXO4-p53 interaction is a dominant survival signal—primarily senescent cells—potentially offering a targeted senolytic effect while sparing healthy, proliferating cells in research models.

Key Research Applications & Potential Investigative Pathways

GENLABS FOXO4-DRI is intended for laboratory research use only. It serves as a critical reagent in the following potential areas of study:

  • Senolysis and Age-Related Research: Investigating the direct clearance of senescent cells from various tissues (e.g., dermal fibroblasts, endothelial cells, hepatocytes) in model systems and observing subsequent tissue function.

  • SASP Modulation Studies: Assessing the downstream effects of senescent cell removal on the inflammatory microenvironment by measuring changes in SASP factors like IL-6, IL-1α, MMPs, and others.

  • Healthspan and Function Studies: Exploring correlations between senolytic interventions and improvements in physiological function, resilience to stress, and tissue regeneration capacity in research models.

  • Model System Development: Utilizing FOXO4-DRI as a positive control or benchmark compound when validating new senolytic agents or cellular senescence assays.

  • Mechanistic Biology: Further elucidating the intricate signaling networks between FOXO proteins, p53 dynamics, and cell fate decisions in the context of stress and aging.

Why Choose GENLABS FOXO4-DRI?

  1. Exceptional ≥98% Purity: Every batch is rigorously analyzed via High-Performance Liquid Chromatography and Mass Spectrometry (HPLC-MS), ensuring minimal impurities and maximum consistency for your experimental results.

  2. Complete Research Kit: Each order contains one 10mg vial of lyophilized FOXO4-DRI peptide and one 10ml vial of sterile, pH-balanced Bacteriostatic Water (0.9% Benzyl Alcohol). This provides everything needed for sterile reconstitution, eliminating sourcing variables.

  3. Stable Retro-Inverso Design: The D-amino acid, reverse-sequence structure offers superior resistance to proteolytic degradation compared to L-peptides, leading to longer activity and more reliable data in cellular and pre-clinical research settings.

  4. Sterile, Lyophilized Format: The peptide is sterile-filtered and lyophilized in a cleanroom environment to ensure stability, longevity, and readiness for precise reconstitution.

  5. Commitment to Research Integrity: GENLABS provides comprehensive supporting documentation, including Certificate of Analysis (CoA) with lot-specific purity data and MS/HRMS verification. Our products are designed solely for use in controlled laboratory settings by qualified researchers.

Reconstitution, Handling & Important Research Notes

Reconstitution Protocol:

  1. Gently swirl the bacteriostatic water vial.

  2. Aseptically, draw the desired volume of bacteriostatic water.

  3. Slowly inject the water down the side of the FOXO4-DRI vial to avoid aggressive foaming.

  4. Gently swirl or roll the vial until the lyophilized cake is fully dissolved. Do not vortex aggressively.

  5. The reconstituted peptide solution should be clear and colorless.

Typical Research Dosage & Storage:

  • In Vitro Concentrations: Research often utilizes concentrations ranging from 1-10 µM, though optimal dosing must be empirically determined for each specific cell type and assay.

  • Post-Reconstitution Storage: The reconstituted solution is stable for approximately 30 days when stored refrigerated at 2-8°C. For long-term stability, aliquoting and storage at -20°C or -80°C is recommended. Avoid repeated freeze-thaw cycles.

  • Lyophilized Powder: Store unopened vials at -20°C or below for long-term stability (up to 24 months).

Disclaimer & Safety Information

INTENDED USE STATEMENT: GENLABS FOXO4-DRI 10mg is sold strictly as a research chemical for laboratory and scientific investigation purposes only. It is not for human or veterinary use, not for ingestion, injection, or any form of personal consumption. It is not a drug, dietary supplement, or cosmetic ingredient. This product has not been evaluated or approved by the FDA or any other regulatory body for the diagnosis, treatment, cure, or prevention of any disease or condition.

Safety: Researchers must handle all peptides using appropriate laboratory safety protocols, including the use of personal protective equipment (PPE) such as gloves, lab coats, and eye protection. Assume all materials require sterile technique for cell culture applications.

Order Your Research Kit Today

Elevate your cellular senescence and longevity research with the precision and quality of GENLABS. Our FOXO4-DRI 10mg kit provides a reliable, high-purity tool to probe the frontiers of senolytic biology. Visit the GENLABS website to view the Certificate of Analysis for this product, explore our full portfolio of research peptides, and place your order.

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  • High-Batch Consistency: GenLabs' manufacturing standards ensure you receive the same effective product with every order.

  • Cost-Effective Therapy: The 100-tablet pack offers a substantial supply, providing an economical, long-term solution for ongoing research and protocol needs compared to brand-name alternatives.

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Final Summary and Responsible Use Statement

GenLabs Arimidex Anastrozole 1mg (100 Tablets) is a potent, selective, and reliable tool for the advanced researcher focused on precise estrogen management. Its role in mitigating estrogenic side effects and supporting overall hormonal equilibrium is well-documented. However, it is a powerful pharmaceutical agent, not a dietary supplement. Respect for its mechanism, coupled with an unwavering commitment to regular blood work and the principle of minimum effective dosing, is essential to harness its benefits while safeguarding health.

Intended Use: This product is strictly for in-vitro laboratory research and educational study of its biochemical properties. It is not for human or animal consumption. By purchasing this product, the researcher attests to understanding its nature and agrees to handle it in a safe, legal, and responsible manner, in compliance with all applicable local, state, and federal laws and regulations.



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Key Features & Professional Specifications

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  • Optimal 2mL Volume: The ideal size for reconstituting smaller-quantity peptides, HCG, growth hormone, or other medications where precise dosing and minimal waste are paramount.

  • Sterility Assurance: Terminally sterilized and sealed under a nitrogen atmosphere to guarantee sterility and stability until the moment of use.

  • Precise pH Balance: Formulated to maintain a pH compatible with a wide range of sensitive biological compounds, promoting stability post-reconstitution.

  • Clean Room Packaging: Each vial is individually packaged to maintain integrity and cleanliness.

Primary Applications & Uses

1. Pharmaceutical & Clinical Reconstitution:
The primary use is to reconstitute lyophilized pharmaceuticals for intramuscular (IM) or subcutaneous (Sub-Q) injection. This includes, but is not limited to, medications prescribed for fertility treatments, hormone replacement therapies, and certain antibiotics supplied in powder form.

2. Research & Peptide Sciences:
In laboratory and research settings, accuracy is non-negotiable. Bacteriostatic Water 2mL is the solvent of choice for reconstituting research peptides, ensuring that the compound's activity is not compromised by contaminants or an unsuitable pH. Its multi-dose capability allows researchers to administer precise, small-volume doses from a single vial over the course of a study period.

3. Compounding Pharmacy:
Pharmacists rely on bacteriostatic water as a trusted diluent for preparing customized parenteral medications, ensuring patient-specific dosages are delivered with a sterile, reliable vehicle.

4. Multi-Dose Convenience:
For patients or protocols requiring frequent, low-volume injections (e.g., daily or bi-daily regimens), a single 2mL vial can suffice for a week or more, reducing packaging waste and cost compared to multiple single-use vials.

Detailed Instructions for Use (Protocol)

Important: Always follow the specific reconstitution instructions provided with your medication or research protocol. Adhere to aseptic technique.

  1. Gather Materials: Bacteriostatic Water 2mL vial, lyophilized compound vial, alcohol swabs, syringe(s) with needle(s) of appropriate gauge.

  2. Sanitize: Wipe the rubber stoppers of both vials thoroughly with an alcohol swab and allow to air dry.

  3. Draw Solvent: Draw air into the syringe equal to the desired volume of bacteriostatic water (e.g., 1mL). Inject this air into the bacteriostatic water vial (to equalize pressure). Withdraw the required volume of solvent.

  4. Reconstitute: Gently inject the bacteriostatic water into the vial containing the lyophilized powder. Aim the stream against the glass wall to avoid forceful agitation. Swirl gently or roll between palms until the powder is fully dissolved. Do not shake vigorously unless specified.

  5. Storage: Label the reconstituted vial with the date and time. Most reconstituted medications are stable for 28 days when refrigerated (2°C to 8°C or 36°F to 46°F) due to the bacteriostatic agent. Consult specific product stability data.

Safety Information & Contraindications

  • NOT for Neonatal Use: Due to the benzyl alcohol content, this product is contraindicated for use in newborns. It may cause fatal "gasping syndrome."

  • NOT for Single-Bolus IV Injection: Bacteriostatic Water is hypotonic (has no electrolytes). It is not intended for direct intravenous infusion or as a standalone IV flush, as it can cause hemolysis (rupture of red blood cells).

  • Allergy Warning: Do not use if there is a known hypersensitivity to benzyl alcohol.

  • Aseptic Technique is Mandatory: Despite the preservative, you must always use sterile needles, syringes, and technique to minimize contamination risk.

  • Discard Promptly: Discard the vial immediately if contamination is suspected or if the 28-day window has passed since first puncture.

Frequently Asked Questions (FAQ)

Q: Can I use sterile water or saline instead?
A: Sterile Water for Injection (without preservative) is for single-use only and must be discarded immediately after reconstitution. Bacteriostatic Sodium Chloride (0.9% benzyl alcohol) is isotonic and often used for diluting already-reconstituted solutions for injection. The choice depends on the medication's specific formulation requirements. Bacteriostatic Water is the standard for multi-dose reconstitution.

Q: Why is the 2mL size beneficial?
A: The 2mL size minimizes "dead space" and overfill waste when reconstituting small-quantity compounds. It provides enough solvent for multiple doses while being space-efficient for refrigeration.

Q: How long does an unopened vial last?
A: When stored in a cool, dry place away from direct light, unopened vials are stable until the printed expiration date, typically 1-2 years from manufacture.

Q: Can I use it for injections into IV bags?
A: No. Bacteriostatic Water is not designed for large-volume parenteral infusion. Its benzyl alcohol content and hypotonic nature make it unsuitable for direct addition to IV bags for patient infusion.

Conclusion: The Essential Diluent for Informed Practice

Choosing the correct solvent is a critical step that directly impacts the potency, safety, and shelf-life of valuable pharmaceuticals and research materials. Bacteriostatic Water 2mL represents the intersection of pharmaceutical rigor and practical utility. Its USP-grade quality, preserved formulation for multi-dose flexibility, and convenient size make it an indispensable tool for healthcare providers, researchers, and compounding specialists who will not compromise on standards.

Disclaimer: This product is a pharmaceutical diluent. It is intended for use only by qualified professionals or individuals under the direct supervision and prescription of a licensed healthcare provider. The information provided here is for educational purposes and does not constitute medical advice. Always verify compatibility with the specific agent you are reconstituting and follow all applicable medical or research protocols.



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