GenLabs IGF-1 DES 1mg: Precision-Engineered for Advanced Tissue Repair & Localized Growth Research
In the pursuit of understanding cellular repair, muscle hypertrophy, and metabolic processes, researchers require tools of exceptional purity and biological activity. GenLabs rises to this challenge with its premium IGF-1 DES (1-3), presented as a lyophilized powder in a 1mg vial, accompanied by a dedicated vial of Bacteriostatic Water (BAC Water) for optimal reconstitution and preservation. This product represents a specialized, potent variant of Insulin-like Growth Factor 1, engineered for targeted investigative applications into localized growth signaling and tissue regeneration.
This comprehensive description details the sophisticated science behind IGF-1 DES, its distinct advantages, the critical importance of the included bacteriostatic water, and the precise handling protocols that define professional-grade research.
IGF-1 (Insulin-like Growth Factor 1) is a fundamental 70-amino acid polypeptide hormone, a primary mediator of growth hormone's effects, playing a central role in anabolism, cellular proliferation, and differentiation. IGF-1 DES (Des(1-3)IGF-1) is a truncated, yet highly bioactive analogue where the first three amino acids (Glu-Pro-Glu) at the N-terminus have been deliberately removed.
This deliberate modification yields a molecule with profound research implications:
Reduced Binding Protein Affinity: The primary biological consequence is a drastic reduction in its affinity for IGF-binding proteins (IGFBPs). In its native form, over 99% of IGF-1 is bound to IGFBPs, which regulate its activity, half-life, and localization. IGF-1 DES's significantly weaker binding allows it to remain in a free, bioactive state for longer periods at the site of administration.
Enhanced Localized Bioactivity: This "escaping" of the binding protein complex means IGF-1 DES can interact more readily and potently with cell surface IGF-1 receptors in the immediate area of application. For research focused on localized tissue response, this makes it a far more direct and potent agent than its native counterpart.
Research-Specific Profile: Its properties direct its utility toward studies investigating autocrine/paracrine signaling—where cells stimulate growth in themselves or nearby cells—rather than systemic endocrine effects.
Every vial of GenLabs IGF-1 DES is manufactured under stringent, controlled conditions to ensure it meets the exacting standards required for reliable, reproducible research data.
>99% Purity Verification: Each batch is rigorously analyzed via HPLC (High-Performance Liquid Chromatography) and Mass Spectrometry to confirm peptide sequence, molecular weight, and exceptional purity, free from contaminants or truncated sequences.
Lyophilized for Stability: The peptide is supplied as a sterile, lyophilized (freeze-dried) white powder in a sealed glass vial. This process removes water while preserving the delicate tertiary structure of the peptide, ensuring long-term stability and potency when stored correctly (recommended at 2-8°C before reconstitution).
Precise 1mg Dosage: The standardized 1mg quantity allows for accurate, consistent dosing calculations and preparation across experimental series.
GenLabs includes a vital component with every IGF-1 DES vial: a separate, sterile 10ml vial of Bacteriostatic Water (BAC Water). This is not merely a convenience but a necessity for professional research practice.
Purpose of Reconstitution: The lyophilized peptide must be reconstituted into a liquid solution to be usable in a research setting. Bacteriostatic Water is the gold-standard diluent for this purpose.
Preservation and Multi-Dose Integrity: Unlike sterile water, BAC Water contains 0.9% Benzyl Alcohol, which acts as a bacteriostatic agent—inhibiting the growth of bacteria. This is essential because a reconstituted peptide vial is often used for multiple administrations over several days. Using plain sterile water creates a risk of bacterial contamination after the first use, which can compromise the peptide's integrity, lead to degradation, and pose a contamination risk.
Optimal pH and Osmolarity: This specialized water is formulated to maintain a pH and osmotic balance compatible with peptide stability and tissue compatibility in research models.
Given its unique pharmacological profile, IGF-1 DES is a compound of interest for advanced research into:
Localized Skeletal Muscle Hyperplasia & Hypertrophy: Studying its potent mitogenic effects on satellite cell activation, myoblast proliferation, and differentiation, leading to increased muscle fiber number and size in targeted areas.
Connective Tissue Repair & Collagen Synthesis: Investigating its role in stimulating fibroblast activity and collagen production, which is crucial for tendon, ligament, and dermal repair mechanisms.
Neurotrophic Effects: Exploring its potential support role in neuronal survival, axonal growth, and myelin synthesis within the central and peripheral nervous systems.
Angiogenesis Research: Examining its influence on promoting the formation of new capillary networks, enhancing local nutrient and oxygen delivery to recovering tissues.
Cellular Uptake Mechanisms: As a model compound for studying receptor-mediated endocytosis and intracellular signaling cascades, particularly the PI3K/Akt and MAPK pathways.
Important Notice: GenLabs products are intended for laboratory research and in-vitro study only. They are not for human or veterinary therapeutic use. Handle all research materials with appropriate PPE and adhere to institutional biosafety guidelines.
1. Reconstitution (Using Provided BAC Water):
* Gently remove the plastic caps from both the IGF-1 DES vial and the Bacteriostatic Water vial. Clean the rubber stoppers with an alcohol swab.
* Using a sterile, large-bore syringe (e.g., 3ml or 5ml), draw 2ml of the provided BAC Water. Note: A standard reconstitution volume of 2ml creates a convenient concentration of 500mcg per 1ml (or 50mcg per 0.1ml/10 IU on an insulin syringe). Researchers may adjust this volume based on experimental needs.
* Slowly inject the BAC Water down the side of the IGF-1 vial, avoiding direct high-pressure stream onto the lyophilized cake. Gently swirl or roll the vial until the peptide is completely dissolved. Do not shake vigorously, as this can cause denaturation.
2. Storage Post-Reconstitution:
* Once reconstituted with Bacteriostatic Water, the solution should be stored refrigerated at 2-8°C (36-46°F). Under these conditions, the solution is typically stable for approximately 7-10 days before significant degradation may occur. It should not be frozen after reconstitution.
3. Administration in Research Models:
* For in-vivo studies requiring localized administration, ultra-fine gauge insulin syringes (e.g., 29-31G) are commonly used for precision. Dosing is highly dependent on the research model, target tissue, and study design. Initial research often involves very low doses to assess localized response.
Specificity: Provides a targeted research tool for studying localized, IGFBP-independent anabolic and repair pathways.
Complete Kit: Includes the necessary Bacteriostatic Water, ensuring proper aseptic technique and peptide stability.
Analytical Confidence: Backed by verified purity certificates from independent laboratories.
Manufacturing Transparency: Produced in a certified facility adhering to high-quality control standards.
Stability: Lyophilized form guarantees extended shelf life and preserved bioactivity.
Disclaimer: This information is for educational and research purposes only. This product is a chemical for laboratory research and is not a drug, dietary supplement, or approved for human consumption. It is the responsibility of the purchaser to conform to all applicable local, state, federal, and international laws regarding the acquisition, handling, and use of research peptides. By purchasing this product, you acknowledge and agree that you are a qualified researcher operating within a controlled laboratory environment.
Order GenLabs IGF-1 DES 1mg/vial today and advance your research into the frontiers of localized growth and repair with a potent, precision-engineered tool.
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