Unlock Unparalleled Muscle Growth and Recovery with GenLabs IGF 1 – DES (1-3) – 2mg/vial
In the relentless pursuit of peak physical performance, accelerated recovery, and superior body composition, advanced researchers are continually exploring the frontiers of peptide science. Standing at the vanguard of this exploration is Insulin-like Growth Factor 1, a pivotal regulator of anabolism. GenLabs, a name synonymous with precision and purity in research biochemistry, introduces a highly specialized and potent variant: IGF 1 – DES (1-3) – 2mg/vial, complete with complimentary bacteriostatic water. This product represents a significant leap in targeted growth factor research, engineered for those demanding rapid, localized, and profound tissue-repairing effects.
To appreciate the innovation behind GenLabs IGF-1 DES, one must first understand its parent molecule, IGF-1. Naturally produced in the liver, IGF-1 is a primary mediator of growth hormone's effects, playing crucial roles in cellular proliferation, differentiation, and survival, particularly in muscle, bone, and nervous tissue. However, in its endogenous form, over 99% of IGF-1 is bound to IGF Binding Proteins (IGFBPs), which regulate its activity and half-life, effectively slowing and systemicizing its effects.
IGF-1 DES (1-3), where "DES" stands for "Des(1-3)," is a truncated, analog form. It has been genetically engineered with the removal of the first three amino acids (glutamic acid, proline, and glutamate) from the N-terminus of the native IGF-1 peptide. This deliberate modification is transformative, conferring two critical advantages for targeted research:
Dramatically Reduced Binding Affinity: The DES variant exhibits an extremely low affinity for IGFBPs. This means it circulates almost entirely in its free, bioactive form, making it immediately available to bind with IGF-1 receptors on target cells.
Potentiated Biological Activity: Studies suggest that the free IGF-1 DES molecule can be up to ten times more potent than its native counterpart in various bioassays, eliciting a much stronger anabolic and proliferative signal upon receptor binding.
The result is a research peptide with a significantly shorter systemic half-life but exponentially greater localized potency at the site of administration, making it an ideal candidate for studies focused on myofibrillar hypertrophy, tendon/ligament repair, and localized hyperplasia.
In a market where consistency and authenticity are paramount, GenLabs sets the benchmark. Our IGF-1 DES is synthesized and purified under stringent cGMP (current Good Manufacturing Practice) guidelines, ensuring every vial meets uncompromising standards.
Ultra-High Purity (>99%): Each batch is verified via HPLC (High-Performance Liquid Chromatography) and mass spectrometry, guaranteeing a product free from impurities, truncations, or filler peptides.
Precise Lyophilization: The peptide is meticulously lyophilized (freeze-dried) into a stable, sterile powder within a sealed, nitrogen-backfilled vial to ensure long-term stability and potency.
Sterile, ISO-Compliant Production: The entire process occurs in an ISO-certified facility, utilizing sterile filters and aseptic techniques to guarantee a contaminant-free product ready for research use.
Third-Party Analytical Verification: Certificates of Analysis (CoA) are available, providing transparent, laboratory-confirmed data on purity, amino acid sequence, and molecular weight.
Understanding that the integrity of a peptide is only as good as its reconstitution, GenLabs includes a complimentary vial of sterile, multi-dose Bacteriostatic Water (0.9% Benzyl Alcohol) with every order. This is not merely an accessory but a critical component:
Preservation: The 0.9% benzyl alcohol inhibits bacterial growth, allowing the reconstituted solution to remain stable and sterile for extended periods when refrigerated (typically 7-10 days).
Optimal pH & Sterility: Specifically formulated for peptide reconstitution, it ensures the peptide goes into solution correctly without degrading.
Convenience & Safety: Researchers receive a complete, compatible kit, eliminating the need to source sterile water separately and ensuring procedural consistency.
GenLabs IGF-1 DES (1-3) is intended for in vitro (cell culture) and in vivo (animal model) scientific investigation. Its unique properties make it a compelling subject for studies in several key areas:
1. Skeletal Muscle Hypertrophy and Hyperplasia Research:
IGF-1 is a master regulator of the PI3K/Akt/mTOR pathway, the primary anabolic signaling cascade in muscle cells. The potent, localized effect of IGF-1 DES makes it ideal for studying:
Myofibrillar Protein Synthesis: Investigating rapid activation of satellite cells (muscle stem cells) and their fusion into existing myofibers to increase cross-sectional area.
Muscle Hyperplasia: Exploring the potential for promoting the division of satellite cells to form entirely new muscle fibers, a phenomenon of great interest in muscle biology.
2. Connective Tissue and Injury Recovery Studies:
Tendons, ligaments, and cartilage have dense populations of IGF-1 receptors. Research can focus on:
Collagen Synthesis: Examining the upregulation of collagen types I and III, the primary structural proteins in tendons and ligaments, for enhanced tensile strength and repair.
Tenocyte & Chondrocyte Proliferation: Studying the mitogenic effects on tendon cells (tenocytes) and cartilage cells (chondrocytes) to accelerate healing in models of strain or overuse.
3. Localized Fat Metabolism (Lipolysis):
While systemic effects are minimized, localized research indicates IGF-1 can enhance lipid metabolism in adipose tissue. Studies may investigate its role in promoting lipolysis (fat breakdown) and inhibiting lipogenesis (fat storage) in site-specific adipose depots.
4. Neurotrophic and Cognitive Function Exploration:
IGF-1 receptors are abundant in the central nervous system. Research avenues include:
Neuroprotection & Synaptic Plasticity: Examining potential protective effects on neurons and the enhancement of synaptic connections, relevant to models of cognitive decline or neural injury.
Peripheral Nerve Regeneration: Studying its role in supporting the repair and myelination of peripheral nerves after damage.
For investigative purposes, proper handling is non-negotiable.
Storage: Keep lyophilized powder refrigerated at 2-8°C (36-46°F). After reconstitution with the provided bacteriostatic water, the solution must be stored refrigerated and used within the stability window (typically 7-10 days).
Reconstitution: Using aseptic technique, slowly inject the bacteriostatic water down the side of the peptide vial. Gently swirl or roll—do not shake vigorously—until the powder is fully dissolved, yielding a clear solution.
Research Considerations: Due to its short half-life (minutes) and potent localized action, research protocols often involve precise, site-specific administration to study acute, targeted effects rather than systemic outcomes.
Unrivaled Potency: The DES (1-3) analog offers a direct, powerful anabolic signal unmatched by standard IGF-1.
GenLabs Quality Guarantee: cGMP synthesis, triple-phase testing, and guaranteed >99% purity.
Complete Research Solution: Includes high-quality bacteriostatic water for immediate, proper reconstitution.
Targeted Action Profile: Ideal for studies requiring localized, non-systemic effects on muscle, connective tissue, and fat metabolism.
Transparency and Trust: Batch-specific third-party CoAs ensure you know exactly what you are researching.
Disclaimer: GenLabs IGF 1 – DES (1-3) – 2mg/vial is sold strictly as a research chemical for laboratory use only, in accordance with all applicable laws and regulations. It is not for human or veterinary use, not for injection, and not for consumption. It is the sole responsibility of the purchasing researcher to handle all products safely and in compliance with local, state, and federal guidelines.
Elevate your research into the mechanisms of growth, repair, and metabolism. Choose GenLabs IGF-1 DES for precision, potency, and unparalleled quality in peptide science.
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