In the evolving landscape of peptide therapeutics, where precision, purity, and biological efficacy are paramount, GenLabs introduces Opinealon 20mg Vial (with Bacteriostatic Water). This professional-grade pharmaceutical product represents a significant advancement in the targeted application of dipeptides for complex neurological and connective tissue disorders. Designed for research, clinical study, and specialized therapeutic protocols, this kit combines a high-purity, lyophilized vial of the innovative peptide Opinealon (GVS-111) with a dedicated vial of USP-grade bacteriostatic water for precise and sterile reconstitution. This comprehensive description delves into the science of Opinealon, its multifaceted mechanisms of action, approved and potential applications, detailed usage guidelines, and the uncompromising quality standards upheld by GenLabs.
Opinealon, also known by its research code GVS-111 or generic name Selank, is a synthetic dipeptide analog (L-pyroglutamyl-L-asparagine). Its development stems from extensive research into endogenous neuroprotective compounds. Unlike larger, more complex peptides, Opinealon’s small molecular size allows for unique biological interactions, primarily functioning as a modulator of the neurotrophic factor system. It is specifically recognized for its ability to mimic and potentiate the effects of key neurotrophic factors, particularly Brain-Derived Neurotrophic Factor (BDNF) and Glial Cell Line-Derived Neurotrophic Factor (GDNF). This targeted action places Opinealon at the forefront of strategies aimed at supporting neuronal health, synaptic plasticity, and cellular resilience against various forms of stress and degeneration.
The therapeutic potential of Opinealon is rooted in its sophisticated, multi-targeted mechanism of action:
Neurotrophic Factor Modulation: Its primary action is the upregulation and potentiation of endogenous BDNF and GDNF. These factors are crucial for neuronal survival, differentiation, and the maintenance of synaptic connections. By enhancing this neurotrophic environment, Opinealon supports the brain's inherent capacity for self-repair and adaptation.
Anti-Excitotoxicity & Neuroprotection: Opinealon demonstrates a protective effect against excitotoxic damage, a process where excessive glutamate activity leads to neuronal injury and death (common in stroke, trauma, and neurodegenerative conditions). It helps stabilize neuronal membranes and mitigate calcium overload, preserving cellular integrity.
Anti-Inflammatory and Anti-Apoptotic Effects: At the cellular level, Opinealon modulates inflammatory cytokine expression and inhibits apoptotic (programmed cell death) pathways. This is crucial not only in neurological contexts but also in mitigating inflammatory damage in connective tissues and other organ systems.
Support for Connective Tissue and Cartilage: Beyond the CNS, research indicates Opinealon stimulates the synthesis of essential extracellular matrix components, including collagen and proteoglycans. This promotes the repair and regeneration of cartilage, tendons, and ligaments, making it a compound of interest in orthopedics and sports medicine.
The Opinealon 20mg Vial by GenLabs is intended for controlled research and clinical exploration under professional supervision. Its applications are supported by a growing body of preclinical and clinical data:
Neurological Disorders & Neurorehabilitation: Investigated for use in post-stroke recovery, traumatic brain injury (TBI), and early-stage neurodegenerative conditions (e.g., Alzheimer's disease, Parkinson's disease) to support cognitive function, motor recovery, and delay progression.
Ophthalmic Applications: A primary and well-researched use is in the treatment of optic nerve pathologies (optic neuritis, glaucoma, ischemic optic neuropathy) and retinal diseases (e.g., retinitis pigmentosa). Its neuroprotective and trophic effects help preserve retinal ganglion cells and photoreceptors.
Psychiatric Conditions: Studied for its potential anxiolytic and nootropic effects, possibly offering a novel approach to managing anxiety disorders and cognitive deficits with a favorable safety profile.
Connective Tissue Repair: Applied in protocols for osteoarthritis, tendinopathies, and cartilage defects. Its anabolic effect on matrix synthesis supports joint health and functional recovery.
General Anti-Aging and Resilience Medicine: Explored for its systemic benefits in enhancing cellular stress resistance, potentially slowing age-related declines in neuronal and connective tissue function.
The GenLabs Opinealon kit is engineered for accuracy, safety, and user convenience:
Lyophilized Opinealon Vial: A sterile, glass vial containing 20mg of ultra-pure (>98% by HPLC), lyophilized (freeze-dried) Opinealon peptide as a white powder or compact cake. The vial is sealed under an inert atmosphere to ensure long-term stability.
Bacteriostatic Water Vial (30ml): A separate vial containing 30ml of sterile, USP-grade bacteriostatic water (0.9% benzyl alcohol). The bacteriostatic agent allows for multi-dose use of the reconstituted solution for up to 28 days when refrigerated, provided strict aseptic technique is maintained.
Professional Packaging: Components are securely housed in a protective box with clear labeling, lot numbers, and expiration dates.
Important Notice: This guide is for informational purposes. Administration must be determined by a qualified healthcare or research professional based on specific protocol needs.
Reconstitution:
Aseptically wipe the rubber stoppers of both vials with an alcohol swab.
Draw the desired volume of bacteriostatic water into a sterile syringe. Common reconstitution volumes for the 20mg vial range from 1ml to 2ml, resulting in concentrations of 20mg/ml or 10mg/ml, respectively.
Slowly inject the bacteriostatic water into the Opinealon vial, directing the stream against the glass wall to avoid aggressive agitation.
Gently swirl or roll the vial until the powder is fully dissolved into a clear, colorless solution. Do not shake vigorously.
Dosage and Administration:
Dosing is highly protocol-dependent. In clinical human studies, typical doses range from 2mg to 10mg per day. Common research protocols often involve:
Subcutaneous (SC) Injection: The most frequent route. After reconstitution, the calculated dose is drawn into an insulin syringe (e.g., 0.1ml of a 20mg/ml solution = 2mg) and administered into subcutaneous adipose tissue.
Intramuscular (IM) Injection: Also used, particularly for musculoskeletal targeting.
Other Routes: Includes retrobulbar or sub-Tenon's injections for ophthalmic conditions (administered ONLY by a specialist).
A standard course often lasts 10 to 30 days, with cycles potentially repeated after a break. The provided 30ml bacteriostatic water vial is ample for safe, multi-dose reconstitution and use.
GenLabs manufactures Opinealon in an ISO-certified facility adhering to cGMP (current Good Manufacturing Practice) guidelines.
Purity & Verification: Every batch is analyzed via High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to confirm identity, purity (>98%), and absence of contaminants.
Sterility & Pyrogen Testing: The lyophilized product and diluent undergo rigorous testing to ensure sterility and are endotoxin-free (LAL test).
Stability & Storage: The lyophilized vial is stable at room temperature for extended periods. After reconstitution, the solution must be stored refrigerated at 2°C to 8°C (36°F to 46°F) and used within 28 days. Discard if cloudiness or precipitation occurs.
Contraindications & Side Effects: Opinealon is generally well-tolerated. Contraindications include known hypersensitivity to the peptide or benzyl alcohol. Use during pregnancy or lactation is not recommended due to insufficient data. Side effects are rare but may include mild transient reactions at the injection site.
The Opinealon 20mg Vial (with Bacteriostatic Water) by GenLabs is more than a pharmaceutical product; it is a sophisticated tool for advancing the frontiers of regenerative medicine. By offering a potent, precisely formulated dipeptide with compelling mechanisms in neuroprotection and tissue repair, it provides researchers and clinicians with a novel agent to address some of the most challenging conditions in neurology, ophthalmology, and orthopedics. Backed by GenLabs' unwavering commitment to quality, purity, and scientific integrity, this kit stands as a reliable and potent option for those dedicated to exploring and applying the next generation of peptide therapeutics.
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