SKU: GL-TB500-10-BW
Category: Research Peptides / Synthetic Compounds
Keywords: TB 500, Thymosin Beta-4, TB-500 10mg, peptide research, injury recovery research, cell migration, angiogenesis, research peptide with bacteriostatic water, GENLABS premium, lab-grade peptide, sterile peptide vial.
Welcome, researchers, to a detailed examination of one of the most intriguing synthetic peptides in modern biomedical study: Thymosin Beta-4 (TB-500). GENLABS is proud to offer this high-purity, lyophilized 10mg TB 500 vial, conveniently bundled with a sterile 30ml vial of Bacteriostatic Water (0.9% Benzyl Alcohol), streamlining your experimental protocol from the outset.
This product page is designed for research professionals only. The information herein is for educational and scientific discussion purposes, detailing the known biochemical properties and research applications of TB-500 as derived from published scientific literature. This compound is sold strictly for in vitro (outside a living organism) laboratory research and is not for human or veterinary use.
TB-500 is a synthetic, laboratory-produced version of the naturally occurring 43-amino acid peptide, Thymosin Beta-4. This endogenous peptide is found in high concentrations in blood platelets, wound fluid, and various cell types throughout the body. Its primary research focus centers on its role as a master regulator of actin, a fundamental protein that comprises the cellular cytoskeleton.
The cytoskeleton is not merely a structural scaffold; it is dynamic, governing cell shape, division, motility, and repair. By binding to actin monomers, TB-500 modulates their polymerization, influencing a cascade of critical cellular processes. GENLABS synthesizes TB-500 to a purity of >99%, ensuring your research is not compromised by impurities or truncated sequences, providing a reliable and consistent tool for your investigations.
Extensive in vitro and animal model studies (as documented in peer-reviewed journals) have highlighted several compelling mechanisms of action that make TB-500 a subject of intense research. Our 10mg vial provides ample material for controlled laboratory studies exploring these pathways:
The most pronounced property of TB-500 is its potent ability to enhance cell migration. By regulating actin, it allows cells such as endothelial cells (which line blood vessels), keratinocytes (skin cells), and mesenchymal stem cells to move more effectively across a substrate. This is a cornerstone process in tissue repair, where cells must travel to a site of injury to initiate healing.
Research indicates TB-500 may upregulate key angiogenic factors like VEGF (Vascular Endothelial Growth Factor). Promoting the growth of new capillaries from existing vasculature is vital for delivering oxygen and nutrients to damaged tissues, facilitating removal of waste products, and establishing a framework for regeneration.
Studies suggest TB-500 can modulate inflammatory pathways, potentially reducing the expression of pro-inflammatory cytokines. By helping to control the excessive or prolonged inflammatory phase of injury, the peptide may create a more conducive microenvironment for the subsequent proliferative and remodeling phases of healing.
The peptide appears to influence the production and organization of ECM components like collagen. It may upregulate matrix metalloproteinases (MMPs) responsible for degrading damaged tissue and increase the deposition of new, structured collagen fibers, potentially improving tensile strength and elasticity of repaired tissue.
Emerging research points to a potential role for TB-500 in promoting cell survival under stressful conditions. It may activate specific cell survival pathways, helping to protect vulnerable cells in the harsh microenvironment of an injury site from programmed cell death (apoptosis).
Uncompromising Purity & Verification: Every batch of GENLABS TB-500 is synthesized using advanced solid-phase peptide synthesis (SPPS) and undergoes rigorous HPLC (High-Performance Liquid Chromatography) and Mass Spectrometry (MS) analysis. A Certificate of Analysis (CoA) is available upon request, confirming amino acid sequence and purity exceeding 99%.
Sterile, Lyophilized Presentation: The peptide is provided as a sterile, lyophilized (freeze-dried) white powder in a sealed, neutral glass vial. Lyophilization ensures maximum stability and longevity when stored correctly, preventing degradation.
Complete Kit with Bacteriostatic Water: We include a sterile 30ml vial of Bacteriostatic Water (0.9% Benzyl Alcohol). The bacteriostatic agent prevents bacterial growth in the reconstituted solution for extended periods under refrigerated conditions, allowing for multi-use in a laboratory setting while maintaining sterility. Note: For certain sensitive in vitro assays, researchers may opt to use sterile saline or other buffers.
Precision Dosage & Consistency: The 10mg quantity is a standard and versatile concentration for laboratory research, allowing for precise molar calculations and serial dilutions to create a wide range of concentrations for cell culture or other experimental models.
Transparent Sourcing & Compliance: GENLABS operates with full transparency. Our peptides are for research use only (RUO). This product is intended for controlled laboratory environments by qualified researchers.
Storage (Unreconstituted): Store the lyophilized vial in a cool, dark place, ideally at 2-8°C (36-46°F). For long-term storage (over 6 months), keeping the vial at -20°C (-4°F) is recommended.
Reconstitution (Aseptic Technique Required): All procedures must be performed in a sterile laminar flow hood using appropriate personal protective equipment (PPE).
Gently tap the lyophilized vial to collect powder at the bottom.
Clean the rubber stoppers of both the peptide and bacteriostatic water vials with a sterile alcohol swab.
Draw a calculated volume of bacteriostatic water into a sterile syringe. The volume determines the final concentration (e.g., 1ml yields a 10mg/ml solution; 2ml yields a 5mg/ml solution).
Slowly inject the diluent down the side of the peptide vial to avoid aggressive force on the powder.
Gently swirl or roll the vial until the peptide is fully dissolved. Do not shake vigorously, as this can cause denaturation.
Storage (Reconstituted): The reconstituted solution should be stored refrigerated at 2-8°C (36-46°F) and used within a timeframe appropriate for sterile laboratory reagents (typically 21-30 days with bacteriostatic water).
Handling: This product is a potent bioactive peptide. Handle with care using appropriate laboratory gloves. Avoid inhalation or direct contact with skin or mucous membranes.
GENLABS TB-500 is a chemical for laboratory research purposes only. It is not intended for diagnostic, therapeutic, or human consumption uses. It has not been evaluated or approved by the FDA or any other regulatory body for the treatment, cure, or prevention of any disease or condition. The sale of this product is conditional upon the buyer's agreement that they are a qualified researcher working within a licensed laboratory setting and will adhere to all applicable laws and regulations governing the handling of research chemicals. By purchasing this product, you attest that you understand and agree to these terms.
The GENLABS TB 500 10mg Kit provides a reliable, high-quality tool to delve into the complex biology of tissue repair, cellular dynamics, and regenerative pathways. Its well-documented mechanisms on actin regulation offer a window into fundamental physiological processes.
Order your GENLABS TB 500 10mg Vial with Bacteriostatic Water today to advance your scientific inquiries with confidence and precision.
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