In the relentless pursuit of advanced health optimization and research into the fundamental processes of aging and cellular dysfunction, a paradigm-shifting compound has emerged: SS-31, also known as Elamipretide. GenLabs is proud to offer the highest purity research-grade SS-31 in a convenient 50mg vial, accompanied by a dedicated vial of Bacteriostatic Water (BAC Water) for precise reconstitution. This product represents a critical tool for serious researchers investigating the intricate world of mitochondrial function, oxidative stress, and cellular resilience.
Unlike traditional antioxidants that diffuse broadly with limited efficacy, SS-31 is a novel, mitochondria-targeted tetrapeptide (D-Arg-Dmt-Lys-Phe-NHâ‚‚). Its ingenious design allows it to accumulate within the inner mitochondrial membrane, the very epicenter of cellular energy production and a primary site of reactive oxygen species (ROS) generation. By stabilizing and protecting this crucial cellular component, SS-31 represents a focused, mechanistic approach to supporting mitochondrial integrity, thereby influencing a vast array of downstream physiological processes critical for peak cellular performance.
To understand the significance of SS-31, one must first understand the mitochondria. These organelles are responsible for producing over 90% of the body's cellular energy in the form of adenosine triphosphate (ATP). This process, the electron transport chain (ETC), occurs across the inner mitochondrial membrane. Over time, and under stress, this membrane can become damaged, leading to electron leakage, excessive ROS production, and a decline in ATP synthesis—a cycle implicated in numerous age-related and degenerative states.
SS-31 works through two primary, well-researched mechanisms:
Electrostatic Interaction & Membrane Stabilization: The unique structure of SS-31, with its alternating aromatic and basic residues, allows it to bind selectively to cardiolipin. Cardiolipin is a phospholipid found almost exclusively in the inner mitochondrial membrane and is essential for the proper structure and function of the ETC complexes. SS-31’s binding helps maintain optimal cardiolipin conformation, stabilizing the membrane architecture and ensuring the proteins of the ETC remain properly assembled and functional. This stabilization alone enhances the efficiency of oxidative phosphorylation.
Potent, Localized Antioxidant Activity: By concentrating within the mitochondria, SS-31 neutralizes harmful ROS like superoxide and hydrogen peroxide at their source, before they can spill into the cell and cause widespread oxidative damage to proteins, lipids, and DNA. This targeted scavenging is exponentially more efficient than systemic antioxidants, protecting the delicate mitochondrial DNA and preserving the organelle's functional capacity.
The synergistic result of these actions is enhanced mitochondrial efficiency, increased ATP production, reduced apoptotic signaling (cellular death), and improved overall cellular vitality.
Mitochondria-Specific Action: Directly targets and concentrates in the inner mitochondrial membrane, the site of energy production and ROS generation, for unparalleled efficiency.
Stabilizes Cardiolipin: Supports the structural integrity of the inner mitochondrial membrane, ensuring optimal function of the electron transport chain and improving cellular bioenergetics.
Source-Located Antioxidant Protection: Scavenges harmful reactive oxygen species at their point of origin, preventing oxidative damage before it compromises cellular components.
Promotes Cellular Resilience: By improving energy output and reducing oxidative stress, SS-31 supports cellular survival mechanisms and may help maintain function in cells under metabolic or environmental stress.
High-Purity, Research-Grade Formulation: GenLabs SS-31 is produced in a cGMP-certified facility, undergoes rigorous HPLC purification (>98% purity), and is sterile-filtered to ensure the highest quality and consistency for research purposes.
Complete Kit: Includes one 50mg vial of lyophilized SS-31 peptide AND one separate vial of Bacteriostatic Water (0.9% Benzyl Alcohol), providing everything needed for accurate, multi-dose reconstitution and storage.
SS-31 is the subject of extensive preclinical and clinical research. Key areas of scientific investigation include:
Mitochondrial Bioenergetics & Function: Studying the direct impact on ATP synthesis rates, oxygen consumption (OCR), and membrane potential in various cell models.
Age-Related Cellular Decline: Researching the peptide's role in mitigating mitochondrial dysfunction, a hallmark of the aging process and sarcopenia (age-related muscle loss).
Neurological Research: Investigating neuroprotective effects in models of neurodegenerative conditions, focusing on the high-energy demands and vulnerability of neuronal cells.
Cardiovascular Research: Exploring support for endothelial function and myocardial cells, given the heart's extreme reliance on constant mitochondrial ATP production.
Exercise Physiology & Muscle Recovery: Examining the potential for improved muscle endurance, reduced fatigue, and accelerated recovery through enhanced mitochondrial efficiency in muscle tissue.
Fibrosis & Tissue Remodeling: Studying impacts on cellular processes related to fibrotic pathways in various organ systems.
Disclaimer: This information is for educational purposes. SS-31 is a research chemical strictly for laboratory use in vitro (e.g., cell cultures) or in controlled preclinical research settings. It is not for human or veterinary consumption.
Reconstitution: Aseptically inject the provided Bacteriostatic Water into the SS-31 peptide vial. Gently swirl or roll the vial until the lyophilized powder is fully dissolved. Do not shake vigorously, as this can denature the peptide.
Dosage Calculation: Research concentrations are typically in the micromolar (µM) to nanomolar (nM) range. Common in vitro concentrations in research studies range from 1nM to 100µM, depending on the cell type and assay. Precise calculation based on molecular weight (SS-31 = 816.98 g/mol) is essential.
Storage: Store the unreconstituted lyophilized peptide at -20°C or below for long-term stability. Once reconstituted with Bacteriostatic Water, the solution should be stored refrigerated at 2-8°C and used within a defined research period (typically 30 days), as the bacteriostatic agent inhibits microbial growth in multi-use vials.
Handling: Always use sterile techniques, gloves, and appropriate laboratory safety equipment when handling.
GenLabs is committed to empowering the scientific community with reliable, high-fidelity research compounds. Our SS-31 offering is backed by:
Independent Third-Party Verification: Each batch is accompanied by a Certificate of Analysis (CoA) from an accredited laboratory, confirming identity, purity (>98%), potency, and sterility.
Manufacturing Integrity: Produced in certified, sterile laboratories adhering to strict quality control protocols.
Stability Assurance: Optimized lyophilization and packaging ensure the peptide reaches your lab with maximum stability and potency.
Transparent Sourcing: We provide clear information on the origin and specifications of our products to ensure reproducibility in your research.
Product Name: SS-31 (Elamipretide) 50mg Vial with Bacteriostatic Water
Catalog Number: GL-PEP-SS31-50
Purity: ≥98% (by HPLC)
Format: Lyophilized white powder
Molecular Formula: C₃₄H₅₉Nâ‚₃O₆
Molecular Weight: 816.98 g/mol
Sequence: D-Arg-DMT-Lys-Phe-NHâ‚‚
Storage: Store at -20°C or below. Protect from light.
Intended Use: For research use only. Not for human consumption, diagnostic, or therapeutic use.
Unlock the potential of mitochondrial medicine in your research. Order the GenLabs SS-31 50mg Vial with Bacteriostatic Water today and explore the frontier of cellular bioenergetics.
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